Back to the Future or Play it Again Sam - some ruminations on how enzymology changes and remains the same.

Cysteine sulfenic acid is of increasing interest and may be more common than expected.

The 4th Edition of the Handbook of Biochemistry and Molecular Biology (ed. Roger L. Lundblad and Fiona MacDonald) has been published by Taylor & Francis/CRC Press. (http://www.crcpress.com)

Personalized Medicine

Some things never change

Cysteine Residues in Factor VIII

Factor VIII Past Present and Future

Oral Protein Drug Delivery and Hemophilia A

Approaches to the Conformational Analysis of Biophamaceuticals by Roger L. Lundblad has been published (January, 2010) by CRC Press ( http://www.crcpress.com )

Therapeutics for Hemophilia A: Where we are, how we got there, and where do we go from here? A seminar in the Department of Pathology at UNC-CH on September 3, 2009

Some thoughts on the development of biomarkers

In Vitro Assays for Therapeutic Enzymes There has been considerable interest in the use of enzyme kinetic analysis in the characterization of therapeutic enzymes. Some considerations are presented for discussion.

Application of Protein Chemistry to Biotechnology is now available from CRC Press/Taylor and Francis

Factor VIII - Reducing Agents, Copper Ions, and Stability Some speculation on free sulfhydryl groups in factor VIII, copper ion and solution stability.

Reducing Affinity in Immunoaffinity Chromatography There are ways to use a polyclonal antibody for immunoaffinity chromatography with reasonable yield.

Promiscuity, Degeneracy and Scientific Discovery It is time for the physicist to come over to help the biologists and then they go back to look for bosons

Salivary Kallikrein and Cancer Detection . A brief discussion of the potential for the use of whole salivary for diagnosis and prognosis in oncology

Talent Dilution and Spatial Separation Increasing size and numbers does not increase productivity. There is a need for more collaboration and less seeking of individual fame and fortune

Musings on Factor VIII - I was recently informed of the passing of Yale Nemerson (February 12, 2009) . I met Yale some 40+ years ago after giving a talk on Factor VIII (see musings) in Atlantic City. I saw him infrequently over the passing years - most recently in NYC in 2007. I will miss Yale as he was a clever person and there are not many left.

Use of Thrombin for the Treatment of Esophageal Varices